9/18/2023 0 Comments Kinase consensus sequence![]() This discussion will review the literature concerning these native and synthetic PKC isozyme-specific peptide substrates and their design.Ĭopyright © 2012 Elsevier Inc. Finally, we demonstrate that the pseudosubstrate sequence of PKC resembles its substrate sequence, directly binds to and inhibits the activity of the kinase. Although a large number of target proteins and synthetic peptides for PKCs are known, only two peptide substrates (peptide 422-426 of murine elongation factor-1α and Alphatomega peptide) have been reported as PKC isozyme-specific peptide substrates. A consensus aPKC's substrate recognition sequence pattern can be readily identified based on the complex structure. Bioinformatics and systems biology approach. Moreover, computational prediction programs of phosphorylation sites using a library of peptide substrates aid in the fast design of PKC isozyme-specific peptide substrates. Consensus sequences and sequence information obtained from PKC target proteins are very important to design PKC isozyme-specific peptide substrates. Thus, PKC isozyme-specific substrates are useful to understand the characterization of the intracellular signaling pathways for each PKC isozyme. Because PKC isozymes directly and/or indirectly participate in signal transduction pathways of normal and transformed cells through phosphorylation of target proteins, it is critical to understand the diversity of the intracellular signaling pathways regulated by each PKC isozyme. Protein kinase C (PKC), a phospholipid-dependent serine/threonine kinase, appears to be involved in the signal transduction response to many hormones and growth factors there are 11 different PKC isozymes. ![]()
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![]() ![]() Jefferson houses over 1,200 sixth, seventh and eighth-graders. However, the in-person attention that students receive at Jefferson is nowhere near comparable to the treatment that university students receive. Jefferson Middle School is only an eight-minute drive from Wake’s campus. Jefferson Middle School, Meadowlark Middle School and Southeast Middle school are three schools within the district that will continue operating as four cohort programs. So, while the majority of high schools and elementary schools are slowly preparing to transition back to in-person instruction, some middle schools are being left behind in the process. According to the WSFCS website, the district is the fourth-largest in North Carolina. The school district serves approximately 55,000 students and employs over 7,200 people. The Winston-Salem/Forsyth County district is home to 80 magnet, non-traditional, elementary, middle and high schools. In a press release posted directly on the Winston Salem/Forsyth County Schools website, it was announced that per the recommendation of Superintendent Tricia McManus, a number of WS/FCS high schools currently using a four-cohort model will transition to a two-cohort model beginning Monday, April 12.īut the Winston-Salem/Forsyth County school district serves a far larger population than a handful of high schools. The legislation that Cooper and his team released on Wednesday stated that individual districts will make the decision of whether or not middle and high schools will operate under Plan A or Plan B. This bill will take effect 21 days after Cooper’s signature hits the page, and the changes it discusses are expected to be instituted sometime around April 1. On Wednesday, March 10, Governor Cooper and a bipartisan team of North Carolina Senate leaders announced a plan that would push all public elementary schools to reopen.Īccording to the legislation Cooper and the North Carolina legislature released, all elementary schools must operate under Plan A. When COVID-19 cases soared across the state in July, Cooper only allowed schools to open using Plan B and Plan C guidelines. Plan C calls for fully remote learning with no opportunity for students or teachers to work within the school building. Plan B limits school capacity to 50% and calls for students to alternate between engaging in in-person and at-home learning. Plan A states that all students are allowed to attend school at the same time, though teachers and older students must wear masks. ![]() Cooper’s school reopening plan that was published over the summer, there are three phases within the North Carolina school reopening strategy: Plans A, B and C. Though Wake Forest University has been offering in-person learning opportunities to students throughout the 2020-21 academic year, other Winston-Salem-based students have not been so lucky - but this is about to change thanks to the leadership of Governor Cooper and Winston-Salem/Forsyth County Superintendent Tricia McManus.Īs highlighted in Gov. ![]() ![]() What Zarina promises: “Designed for Singaporean jobseekers, it’s good to make the process of resume writing and interview coaching for you as simplified as possible. What this site promises: “Land your dream job with captivating CVs you can professionally customize, to reflect your true potential with Canva’s free resume templates and easy-to-use design editor.” Workforce Singapore’s resume starter pack ![]() They’re all designed to help you create a professional quality resume & cover letter that help you get interviews and land a dream job!” What this site promises: “Over 500 examples and articles authored by certified and professional resume writers. Easy to use and done within minutes – try now for free!” What this site promises: “Use professional field-tested resume templates that follow the exact ‘resume rules’ employers look for. With CVmaker, you can create and manage several different resumes in an organised way through your own personal account hub.” Resume.io What this site promises: “Often, it is important to be able to tailor your resume based on the job you wish to apply for. Raring to get going on your resume? Here’s a quick list of some online tools and starter packs that you might want to consider! “For example, this can include leadership skills, communication skills, project management, or events organization.” Connect with hiring employers at various career events such as walk-in interviews, virtual job interviews, virtual career fairs, and many more! Looking for a job? Explore a range of career opportunities with Career GRIT. ![]() Zarina believes so, revealing: “For fresh graduates, showcasing extra-curricular activities can help, especially when the activities demonstrate skills and qualities desired by employers. In a Singapore context, one thing local jobseekers might wonder is whether adding those extra-academic activities taken during your schooling days, or simply personal passions that you enjoy, really helpful in getting a potential employer’s attention on a resume? Are adding extra academic activities from school or personal hobbies on your resume really relevant? “For example, employers will always prefer to see a career summary at the top of the resume, summarising your overall work experiences”, she added. Zarina shared: “While these resume templates are indeed useful, jobseekers also need to ask themselves: will this resume format help to sell their skills and experiences, and catch an employers’ attention?”įormat also matters, of course. However, this doesn’t just mean you only use the standard templates found on such sites without edits or tweaks. Need personalised guidance in your job search? Register for a complimentary session with WSG’s Career Matching Services today and get the support you need. All you need to do is fill in your professional information.”įor some background, Zarina specialises in helping professionals through career exploration and coaching on resumes, job interviews and professional branding, and has helped over 3,000 professionals, managers, executives and technicians (PMETs) to move into careers that align with their interests, strengths and values! ![]() “These sites simplify your resume writing process with ready resume templates. Zarina Abu Bakar, a certified Career Practitioner with 13 years of experience with Workforce Singapore (WSG), believes these resume builders can be of great help if you’re looking to build your resume. Thanks to various free online resume creation tools available, it’s not that hard to create a winning resume! What you want is your professional persona to showcase how you fit the job and industry you’re gunning for. ![]() In this day and age, asking your friend to email you their chio resume template and then simply cutting and pasting your own career details doesn’t quite cut it. ![]() ![]() ![]() New employees will receive instruction as part of their onboarding, but those who already work for you will need training in the new system, too. Provide training to every employee on how to use the clock. Use geo-restrictions to limit where your employees can clock in if the fingerprint scanner won’t work. Have an alternative clock-in option available in case of a repeated failure. Provide wipes or hand sanitizer near the clock. This commonly happens when the fingerprint reader can’t register the employee’s fingerprint due to dry, wet, or dirty skin. The solutions don’t need to be complicated.įor example, sometimes there are false negatives with biometrics. Your employee training will include this information. This policy should cover everything from data security to keeping surfaces sanitized to clock failures. Once you have the clock installed, now what? Have a policy in place.Īs mentioned earlier, be sure you have a comprehensive policy in place regarding your time clock. Integration between the device and its software, and other related systems you’re using, is crucial. You may want to talk to your payroll or scheduling software provider to find out what devices they recommend and then choose from those options. You can find a biometric time clock online, as a stand-alone device, quite easily. That’s the basic setup all systems will have. The software converts that data to a digital format. How to Use a Facial Recognition and/or Fingerprint Time ClockĮvery biometric time clock system will require three basic things: the device, software, and a database of employees. Even if you have few restrictions, your company will want to define compliance and security measures regarding the handling of biometric data. ![]() Check with your state or a lawyer to find out if there are any restrictions to be sure you’re in compliance with current laws. However, in many other states, biometric time clocks are allowed. Labor departments have also interpreted current laws in ways that restrict biometric time clocks. Some courts have also ruled in favor of employees who refuse to use biometric time clocks due to religious concerns. Each of those states’ laws has different restrictions, use scenarios, and storage of data requirements in regards to biometrics. These states all have Biometric Information Privacy Acts (BIPA) that regulate how biometric time clocks can be used. The data you gather to identify each employee has been considered, in differing degrees, as intrusive and invasive in Illinois, Texas, and Washington. Some employees may not want you to collect their biometric data-and some states agree that there is a question of privacy rights. The accuracy will be improved as well.Īll of these benefits will help your bottom line and save you money. If you haven’t made the step to automatic time clock systems, you’ll find that they also save you time manually entering time card data into your payroll system. Most biometric time clocks integrate into a system you already have. The accurate time records you’ll generate from a biometric time clock make it easier to audit and track unnecessary overtime, late or absent employees, or other related issues. Many systems work using a mobile device, so for companies that have workers across the world or out in the field, biometrics work well. You can be assured that the employee is actually present when they say they are. They also make it easier to manage remote employees. They make it impossible for employees to “pad” their hours and add the extra time they didn’t work. Employers lose millions to this practice, and preventing buddy punching has always been a challenge. Biometric clocks end the problem of “buddy punching,” which is when an employee punches in for another employee. Biometric time clocks change all of that. Traditional time clocks have made this easy. Unfortunately, people are good at finding loopholes or ways to game a system. Benefits of Biometric Time Clocks For Your Business Whatever the device uses, the measurement it takes is unique to each employee and cannot be faked. It might be an iris or retina scan, or facial recognition. It might be measuring a vein pattern or hand geometry. That measurement might be a hand scan or a fingerprint. Instead of using badges, punch cards, or PIN codes, a biometric time clock uses a unique body measurement when employees clock in. What Is A Biometric Time Clock?Ī biometric time clock does away with the traditional time clock. Time clocks give you crucial data.īiometric time clocks provide even better data. Hopefully, you don’t need to be convinced as to why you need to use a time clock. You can’t make solid adjustments without data. That means being able to adjust quickly to change. Your business exists in a time when maximum flexibility is required in almost every industry. Or maybe they have no idea how bad it isn’t working for them. Some companies are so into the honor system, they don’t even use a time clock. ![]() 9/18/2023 0 Comments T shaped shower door sweep![]() ![]() ![]() You may want to contact a structural pest management service.ĬAUTION: Mention of a pesticide or use of a pesticide label is for educational purposes only. Pay particular attention to the south and west sides where the insects are most numerous. Some examples of effective active ingredients in pesticides are:Īpply around doors, windows and roof lines. Apply in late September or early October, before insects begin to enter buildings. Use a residual insecticide barrier to limit the entry of lady beetles. This will not eliminate all lady beetles but it will reduce the number entering buildings.Install a rubber seal along the bottom of garage doors. Install door sweeps or thresholds to all exterior entry doors.Repair or replace damaged screens in roof and soffit vents, and in bathroom and kitchen fans.Repair or replace damaged window and door screens.Seal with caulk or, for larger spaces, use polyurethane expandable spray foam, steel wool, copper mesh or another appropriate sealant.Seal areas where cable TV wires, phone lines, and other utility wires and pipes, outdoor facets, dryer vents and similar objects enter buildings.Seal cracks with caulk, such as silicone, elastomeric latex or silicone/acrylic. Check for gaps and cracks where different materials meet, such as brick and wood siding. Seal cracks and spaces around doors, windows and fascia boards.Make any necessary repairs by the end of September. ![]() Lady beetles can fit through openings as small as 1/8 inch in size.Check the outside of your home for spaces and cracks that may allow insects easy entry.Preventing entry is the most effective step. How to protect your homes from lady beetles Picking up fallen apples and removing damaged apples still on the tree will help reduce the number of lady beetles on apple trees.Ripe or nearly-ripe apples may be seen with fairly large cavities in them and a number of lady beetles inside eating the apple’s flesh.These insects only infest apples that already have wounds, such as holes made by birds or other insects.When they run out of their preferred food source (aphids), these lady beetles fly to another food source, often fall-ripening fruit such as grapes, apples and fall raspberries. Exposure to dead lady beetles in buildings can cause allergic reactions in some people.Īsian lady beetles are common in wooded areas, agriculture fields and home gardens.This liquid can stain light-colored surfaces. They can secrete a strong-smelling yellowish liquid from the joints of their legs.These bites happen when the beetles are searching for moisture or food. Some can bite hard enough to break human skin, causing minor, short-lived discomfort.Some concerns with multicolored Asian lady beetles are: These lady beetles cannot sting and do not carry disease.They do not infest wood, destroy fabrics, eat food or damage other property.Multicolored Asian lady beetles can be a nuisance when they occur in large numbers inside homes. Multicolored Asian lady beetles infesting an apple Larvae are blue to black with two orange stripes, and rows of small, spines on their bodies. The immature larvae are alligator-like and appear similar to other lady beetle larvae.The 'M' can look thick, thin or even broken in appearance.Look for the clear black 'M'-shaped marking behind its head, to correctly identify the multicolored Asian lady beetles.These lady beetles may also have fewer than 19 spots and some may have no spots at all.This beetle typically has 19 black spots which can vary in appearance from well-defined to no more than faint traces on its wing covers.It can be seen in a range of colors, ranging from orange to yellow to red or even (rarely) black.The multicolored Asian lady beetle looks very similar to other lady beetles but is generally larger, about 1/3-inch long. How to identify Asian lady beetles Adult beetles Multicolored Asian lady beetle, Harmonia axyridis (Pallas) is also known as Asian lady beetle, Halloween lady beetle, and Japanese lady beetle. These are beneficial insects to farmers and gardeners.Multicolored Asian lady beetle and other lady beetle species feed on aphids and other soft-bodied insects that can damage plants in agricultural crops, gardens and landscapes.Control measures should only be used to prevent entry of Asian lady beetles indoors.They cluster around buildings in large numbers during fall in search of protected sites for the winter.The multicolored Asian lady beetle has become a nuisance in Minnesota. ![]() 9/18/2023 0 Comments Simply fortran 2 source programs![]() As for those who want to install the program on their own systems, they can find it in many popular marketplaces, such as liveware. For those people who would like to try out the Simply Fortran package, you can download it from their website for free. It is available in both Microsoft Windows and Linux flavors. ![]() The developers claim that they have taken every important feature available and improved upon it. ![]() In summary, Simply Fortran is an easy to use professional quality integrated development environment (IDE) with powerful features for numerical analysis and simulation, analysis and exploration, graphing, statistical computing, optimization, tracing, integration with databases, and much more. Furthermore, Simply Fortran has included an integrated development environment that comes included with the software. Fortran fixed-format code is thus treated as a first class language in the editor of Simply Fortran. Simply Fortran supports many different modules, code, and generic components. If unchecked, the debugger will not issue any warning. This situation may arise when debugging a program that uses external libraries. Simply Fortran is a user-friendly professional quality integrated development environment, which can be used to develop both object and executable applications. With this option enabled, Simply Fortran will display a warning if the source file specified by the debugger cannot be found on the system. The two Fortran compilers supported are gfortran and ifort. Simply Fortran was initially released for the IBM Model M line of computers and is now rapidly gaining in popularity with other brands of computers. The program first scans all Fortran files for imports of other source files and creates a. National Institute of Mathematics (NIMA), the United States Department of Energy (DOE), and the National Academy of Sciences (NAS). It was developed by a joint research effort of the U.S. 1.1.1 Simple Fortran II program 1.1.2 Simple Fortran IV program 1.1.3 Simple Fortran 77 program 2 'Retro' FORTRAN IV 2.1 Hello, World program 2.1.1 FORTRAN 66 (also FORTRAN IV) 2.1.2 FORTRAN 77 2.1.3 Fortran 90 3 Fortran 77 examples 3.1 Greatest common divisor 3.2 Complex numbers 3. ![]() Top 4 Download periodically updates software information of Simply Fortran 3.2 B2981 full version from the publisher, but some information may be slightly out-of-date. Simply Fortran is ideal for scientific and engineering numerical applications requiring high numerical sophistication and expression capability. This utility is an excellent tool for comparing source code versions since it allows you to correct the source code and also supports syntax highlighting for. Simply Fortran is a free software for optimizing the performance of numerical analysis with Fortran 95 programming language. The Simply Fortran package includes a configured Fortran compiler, an integrated development environment, including an integrated debugger, and a collection of. ![]() 9/18/2023 0 Comments Youtube contra rebirth stage 2![]() ![]() Overall, Contra ReBirth was received positively, with GameRankings rating the game 76.67% positive, and Metacritic giving the game 76/100. The official album was released on March 24, 2010, in a compilation with Castlevania: The Adventure ReBirth's music. The music consists of remixes of previous Contra themes. The game's soundtrack was composed by Manabu Namiki, who worked on the other titles in the " ReBirth" series. Soundtrack Main article: Castlevania: The Adventure ReBirth & Contra ReBirth Original Soundtrack The game consists of five stages however, the final boss stage, along with the true ending, cannot be accessed when playing on the Easy difficulty setting. Playing on the Easy setting will allow the player to always keep their current weapon after losing a life, a feature not available in any of the other settings. The traditional Flame Thrower, however, is missing. ![]() The power-ups in this installment consists of a Spread Shot, a Laser Gun, and a Homing Gun. The dual weapon system from Contra III: The Alien Wars returns and the player's normal gun can now shoot in auto-fire once again. Two additional characters: BR-W9 (also known as "Brownie" and called Tsugu-Min in the Japanese version), an android shaped like a little girl and Plissken, a tall lizard-like humanoid alien (whose name is a tribute to the Snake Plissken movie character), can also be selected once the player has completed the game on Easy (BR-W9) and Normal (Plissken). The player initially has a choice between two different player characters: Bill Rizer, the traditional Contra hero, or Genbei Yagyu, an alternate incarnation of the protagonist from Neo Contra. As with most Contra games, up to two players can play simultaneously. The game can be played with the standard Wii Remote, as well as with the Classic Controller or a Nintendo GameCube controller. In the true ending of the game, it is revealed Chief Salamander was actually Plissken all along, who infiltrated the Contra unit under an assumed name.Ĭontra ReBirth retains the same sprite-based side-scrolling gameplay as the series' earlier installments. However, Chief Salamander is nowhere to be found. ![]() With the help of BR-W9, an android shaped like a little girl, and Newt Plissken, a tall lizard-like humanoid alien, the Contra warriors manage to take down the Neo-Salamander Force. Bill Rizer and Genbei Yagyu, two members of the present day Contra team, are deployed by the Galactic President to travel back in time in order to stop them. They end up setting base on the ruins of the Shizuoka temple at the Yucatán peninsula in Central America. In 2633, the Neo-Salamander Force, led by their mysterious leader Chief Salamander, travels to the year 1973 to eliminate the " Contra" force while Earth's defenses are still primitive and are no match to theirs. ![]() 9/18/2023 0 Comments Mgba osx tar xz file![]() ![]() The you ftp-ed to the hard drive is not a real tar.xz file, its most likely a tar.gz. While installing to HDD I'm getting tar: invalid magic Some distro don't have ds4drv preinstall (Cutefish for the exemple here) use the store (pamac) to install ds4drv (it's recommend to install the motion control one) then open a terminal, connect you'r ds4 in usb and run ds4drv -hidraw. I can't use my controller as a mouse why ? Some apps not launch why ?įlatPak apps seems to have some problems with the ps4, and Snaps apps is not working, not real fix here use AUR. This can be caused by the kernel or the distro, not real fix here use a wifi or/and a bt dongle. Make sure you'r display is compatible with the 1080p resolution, if you still have a black screen try a others monitor. I still have a black screen even with the kernel 4.14 It's a 'bug' in the 5.x kernel you need to refresh the HDMI the most easy way it's to wait until you get no signal then moved the mouse or pressed a key on the keyboard. To unistalling a OS install on the HDD just delete the Arch.img file in /usr/home. Optional - Unistalling the OS on the HDD. To unistalling a OS install on a USB Device just format the USB Device.
9/18/2023 0 Comments Condense pdf file![]() ![]() You can rest assured that the documents and data used with WinZip PDF Pro are 100% secure. Because WinZip PDF Pro isn’t connected to the internet, we don’t host any documents on the cloud, or view anything that comes through the program. And speaking of security… Will My Compressed File be Secure? Through the software, you can edit them to make changes to the content, convert them to and from other file types without changing the formatting, merge multiple documents into one, and even lock and unlock them to keep a high level of security. That’s why we built WinZip PDF Pro as an all-round hub for your PDFs. If you handle a lot of PDFs on a regular basis, we want to give you the power to do something with them beyond making them smaller. WinZip PDF Pro can convert a wide range of file types to and from PDFs, including Word, Excel, PowerPoint, image files and many more - all without connecting to the internet. It’s designed with offline working in mind, so you can read, edit, compress, and convert PDFs from anywhere - no internet connection required. As long as you can open it, you can compress that PDF into something much more manageable. So if you’re faced with an enormous PDF packed full of images and dense volumes of text, don’t worry. Your only limitations will come from what your computer can handle. With WinZip PDF Pro, there is no limitation to file size whatsoever. What is the Maximum Size PDF file I can compress? Both results look great, but we’ll leave it up to you to decide what’s more important for your needs. When compressing PDF documents, you can choose between basic compression - compressing your files by 40% while keeping high quality content - and strong compression - compressing your files by 75% while keeping good quality content. We built WinZip PDF Pro with the latest technology that makes that trade-off as minimal as possible, and give you two possible options to suit your needs. When reducing the size of a PDF, there’s going to be a trade-off between the quality of the document and the size of the document. Select “Minimum size” to get a reduced file size with clear text and images.How do I Compress a PDF Without Losing Quality?
9/17/2023 0 Comments Bjs happy hour![]() The best part is most of their domestic bottles are only $3 each. The prices at BJ’s happy hour are pretty reasonable compared to other restaurants that offer similar menus. Whether you like beer, wine, or mixed drinks, there are plenty of options at BJ’s Brewhouse. Therefore, if you’re looking for an excuse to enjoy delicious appetizers and a cold drink after work, BJ’s has a great happy hour menu. The offer is available to anyone who visits during happy hour. It doesn’t matter whether you’re visiting the restaurant for the first time or a regular customer. SEE: Sonic Breakfast Hours and Menu What is BJ’s Brewhouse Happy Hour?īJ’s Brewhouse Happy Hour is a discount offer on appetizers, pizzas, and drinks for BJ’s customers. Therefore, I will recommend you check in with your local BJ’s restaurant to confirm their hour of operation. I must say, the timing above might not be applicable to all BJ’s locations. But with their opening time which is 11 am, it is not a place you can grab breakfast before starting your day.įor dine-in, To-Go, curbside, and delivery, below are the BJ’s Brewhouse operation hours every day of the week: What Time Does BJ’s Brewhouse Open?īJ’s Brewhouse is open every day of the week (Monday through Sunday). ![]() The restaurant pride itself on serving premium food and beverages in an inviting atmosphere where you can relax with family and friends.īJ’s Brewhouse serves big portions of delicious American food that are sure to keep you coming back for more, whether you’re here for lunch with the family or dinner with friends or coworkers. Today, BJ’s has grown from a single brewpub to a collection of restaurants across the nation, each with its own local personality.īJ’s Brewhouse celebrates quality, freshness, and taste with a unique combination of award-winning craft beers and casual dining at our wide selection of restaurants across the country. ![]() Some specials are available for long periods of time (some never finish!) while others last a very short amount of time, so it does balance out.BJ’s Brewhouse has been dishing out fresh and flavorful dishes since it was founded in 1978 in Santa Ana, California, United States. That is another great factor regarding Popeyes specials – they are constantly changing! While this can be a drag if you happen to find a special that you love and cannot get enough of until it is no longer available, finding something new and amazing is always a bonus! Popeyes specials will change from time to time. Anyone who is a lover of the famed secret coating found at Popeyes always returns for another helping in the near future, how much better can it be when you get to save some money? That’s exactly what you can expect with Popeyes specials, so always be sure to take advantage of them, as you never know when they could be finishing to start a new promotion! That means that their two favourite items on the menu can regularly be available with great deals, discounts and combinations to give you even more value for money. It could be a combo meal for one or a family meal for to feed a few mouths – there are plenty of specials to be found to suit your needs!Įven the seafood selections are often included in Popeyes specials. ![]() ![]() Popeyes specials take things that bit further, allowing plenty of your favorite sections to be available for even cheaper! It could be through a combo meal that allows you to get some chicken tenders along with fries, a nice cold soda, some tasty buttery biscuits and a trademark dipping sauce to create an awesome meal for next to nothing! With so many chicken selections available, you really can save on so many different items through Popeys various specials. ![]() |
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